Thanks to the efforts of Chris Spencer at Fantasy Baseball Trade Market, I have put together a Target Rankings spreadsheet based on my projections for the top 350 (actually, with the adjustments I made to the list, both are now 349) pitchers and batters in MLB for 2010. The fun part about this tool is that it let's you rank your roster after a draft by selecting the players you drafted and with a simple SUM function, see how close you are to your leagues targets out of the gate. You can then adjust your roster to adapt to the perceived deficiencies on your team. Here is the link to a 10 team league and a 12 team league spreadsheet. You can adjust the results by altering the values on the BB target worksheet, changing the number of hitters and/or pitchers your league uses and of course, the target values you need to succeed.
Note: Both the 12 team and 10 team spreadsheets are available on Scribd, too.